Results of the open field test obtained 2 (a), 6 (b), and 24 h (c) after the administration of zymosan (1, 10, or 100 mg/kg) or saline in mice. Columns and error bars represent mean ± standard error of the mean (SEM). *p < 0.05; **p < 0.01, and ***p < 0.001 compared with the saline-treated group