Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Jan 4;62(2):93–103. doi: 10.1007/s12576-011-0185-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Physiological Society of Japan and Springer 2011

PMC Copyright notice

Fig. 2 — Inhibition of capsaicin-activated TRPV1 current (I _TRPV1,Cap) by hypoxia. a Representative current trace showing response to hypoxia during activation by 200 nM capsaicin. Vertical lines reflect current responses to the repetitive ramp-like pulses from −80 to 80 mV every 10 s. Right summary of inward currents at −20 mV in response to 200 nM capsaicin (normoxia, Control), capsaicin + hypoxia [3% (n = 10) or 9% (n = 7), closed bar and hatched bar, respectively], and capsaicin + reoxygenation (Reoxy). In each cell, current amplitudes were normalized to the control current induced by 200 nM capsaicin. b An exemplary current trace at −20 mV holding voltage showing the repetitive activation of TRPV1 by 50 nM capsaicin (horizontal line). Hypoxia was applied between the second and the fourth applications of capsaicin. Note that the basal current was increased by hypoxia while the amplitude of transient inward current (I _TRPV1,Cap) was decreased. Right summary of amplitudes of I _TRPV1,Cap normalized to the first response (hatched bar) and their changes by 3% (n = 5, closed bars) and 9% (n = 14, open bars)

Inline graphic — Inhibition of capsaicin-activated TRPV1 current (I _TRPV1,Cap) by hypoxia. a Representative current trace showing response to hypoxia during activation by 200 nM capsaicin. Vertical lines reflect current responses to the repetitive ramp-like pulses from −80 to 80 mV every 10 s. Right summary of inward currents at −20 mV in response to 200 nM capsaicin (normoxia, Control), capsaicin + hypoxia [3% (n = 10) or 9% (n = 7), closed bar and hatched bar, respectively], and capsaicin + reoxygenation (Reoxy). In each cell, current amplitudes were normalized to the control current induced by 200 nM capsaicin. b An exemplary current trace at −20 mV holding voltage showing the repetitive activation of TRPV1 by 50 nM capsaicin (horizontal line). Hypoxia was applied between the second and the fourth applications of capsaicin. Note that the basal current was increased by hypoxia while the amplitude of transient inward current (I _TRPV1,Cap) was decreased. Right summary of amplitudes of I _TRPV1,Cap normalized to the first response (hatched bar) and their changes by 3% (n = 5, closed bars) and 9% (n = 14, open bars)