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. 2012 Jan 4;62(2):93–103. doi: 10.1007/s12576-011-0185-4

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Fig. 3 — No effect of hypoxia on acidic pH-activated TRPV1 current (I _TRPV1,Acid). a Representative current trace at −20 mV holding voltage showing the response to acidic condition (pH 6.2) in GFP-only (left) and TRPV1 + GFP-expressed (right) HEK293T cells. A transient inward current was induced by the acidic pH in both cell groups whereas a sustained inward current was additionally observed in the TRPV1-expressed cells. The pH-activated transient current was abolished by 30 μM amiloride, a blocker of ASIC (see inset). b TRPV1 was repetitively activated by acidic pH, and hypoxia ( 3%) was applied between the third and the fourth application of pH 6.2. c Summary of the inward currents normalized to the first response (n = 20)

Inline graphic — No effect of hypoxia on acidic pH-activated TRPV1 current (I _TRPV1,Acid). a Representative current trace at −20 mV holding voltage showing the response to acidic condition (pH 6.2) in GFP-only (left) and TRPV1 + GFP-expressed (right) HEK293T cells. A transient inward current was induced by the acidic pH in both cell groups whereas a sustained inward current was additionally observed in the TRPV1-expressed cells. The pH-activated transient current was abolished by 30 μM amiloride, a blocker of ASIC (see inset). b TRPV1 was repetitively activated by acidic pH, and hypoxia ( 3%) was applied between the third and the fourth application of pH 6.2. c Summary of the inward currents normalized to the first response (n = 20)