Fig. 5.

Effects of genetic deletion of TRPC3 and TRPC6 on the [Ca²⁺] transient in cardiomyocytes from 129/Sv mice during the stretch protocol. a Representative traces of the slow increase in [Ca²⁺] transient during the sustained stretch (SSC) on single cardiomyocytes isolated from 129/Sv wild-type (WT), Trpc3 ^−/−, and Trpc6 ^−/− mice. b Summarized data for the stretch-induced change in [Ca²⁺] transient in cardiomyocytes from WT mice (n = 12). c The stretch-induced slow increase in [Ca²⁺] transient at 300 s after the stretch (SSC), seen in the WT mice, was suppressed in the Trpc3 ^−/− and Trpc6 ^−/− mice (n = 11 and 8). Deletion of TRPC3 and TRPC6 did not affect [Ca²⁺] transient at initial state and 10 s after the stretch. # P < 0.05 vs initial state; * P < 0.05 vs stretch (10 s). TRPC transient receptor potential canonical, Trpc3 ^−/− transient receptor potential canonical subtype 3 knockout, Trpc6 ^−/− transient receptor potential canonical subtype 6 knockout