Fig. 8.
Proposed mechanism of the SSC. Stretch triggers AT1R activation of PLC via Gq to produce DAG. Increased DAG production activates TRPC3/6. The activation of sarcolemmal TRPC3/6 increases the intracellular cation (Na+ and Ca2+) influx. It contributes to intracellular Ca2+ accumulation via indirect effects of TRPC3/6-mediated Na+ influx on NCX activity, or via direct TRPC3/6-mediated Ca2+ influx. AT1R angiotensin II type 1 receptor, PLC phospholipase C, DAG diacylglycerol, NCX Na+/Ca2+ exchanger, TRPC3/6 transient receptor potential canonical subtype 3 and transient receptor potential canonical subtype 6