Fig. 3. (a) Definition of vectors n1 and n2, and geometric parameters d, r, φ1, φ2 and θ. 1,2-Disubstituted bicyclo[2.1.1]hexane is shown as an example. (b) Geometric parameters d, r, φ1, φ2, and |θ| for ortho-substituted benzenes (valsartan and telmisartan); and bicyclo[2.1.1]hexanes 1b, 4b, and 12b. aData are taken from ref. 25a. bData are taken from ref. 25b. cTwo molecules of telmisartan are present in the crystalline lattice with r = 1.385(7)Å and 1.395(7)Å (ref. 25b).
