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. 2023 Dec 13;108(1):45–71. doi: 10.1097/TP.0000000000004624

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Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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FIGURE 16. — Relationships between %dd-cfDNA, molecular archetype groups, and the AMR_Prob and TCMR_Prob classifier scores in N = 300 samples.⁸⁶ Dots represent biopsies and corresponding paired blood sample %dd-cfDNA results, colored by archetype cluster assignments. Regression lines (dashed) show the relationship between the (A) AMR_Prob and (B) TCMR_Prob classifier scores and %dd-cfDNA. Spearman correlations with dd-cfDNA were stronger for AMR_Prob (0.52, P = 6E-22) than TCMR_Prob (0.22, P = 9E-5). AMR, antibody-mediated rejection; dd-cfDNA, donor-derived cell-free DNA; EAMR, early-stage AMR; LAMR, late-stage AMR; NR, no rejection; TCMR, T cell–mediated rejection.