FIGURE 6.

Visualizing archetypal groups in 1679 kidney transplant biopsies.¹⁰⁸ The 1679 biopsies are shown distributed by their rejection classifiers scores in PCA and colored by their archetype assignment, with y-axis PC2 and x-axis (A) PC1 or (B) PC3. (A, rejection increases with PC1, whereas PC2 separates TCMR from AMR). B, PC3 separates AMR stages but does not separate TCMR1 and TCMR2. AMR, antibody-mediated rejection; EAMR, early-stage AMR; FAMR, fully developed AMR; LAMR, late-stage AMR; PCA, principal component analysis; TCMR, T cell–mediated rejection.