TABLE 2.
Main kidney classifiers developed during the MMDx-Kidney project
| Rejection or injury | Category | Name | Description—trained on and predicting: |
|---|---|---|---|
| Rejection-related classifiers | TCMR-related | i-score (i>1Prob) | probability of histologic i-lesion score > 161 |
| t-score (t>1Prob) | probability of histologic t-lesion score > 161 | ||
| TCMR (TCMRProb) | probability of histologic TCMR diagnosis60 | ||
| AMR-related | AMR (AMRProb)a | probability of histologic AMR diagnosis62 | |
| Glomerular double contours (cg>0Prob) | probability of histologic cg-lesion score > 061 | ||
| Peritubular capillaritis (ptc>0Prob) | probability of histologic ptc-lesion score > 0. | ||
| Glomerulitis (g>0Prob) | probability of histologic g-lesion score > 061 | ||
| DSAProb | probability that biopsies with be from DSA-positive patients63 | ||
| All rejection-related | Rejection (RejProb) | probability of any histologic diagnosis of rejection64 | |
| Injury-related classifiers | Recent injury-related | lowGFRProb | probability of GFR ≤3065 |
| Atrophy-fibrosis | ci-score (ci>1Prob) | probability of histologic ci-lesion score > 166 |
a
The abbreviation AMR is used by journal convention but official abbreviations used in the MMDx papers and website is usually “ABMR.”
AMR, antibody-mediated rejection; cg, transplant glomerulopathy; DSA, donor-specific antibody; g, glomerulitis; GFR, glomerular filtration rate; i, interstitial inflammation; ptc, peritubular capillaritis; t, tubularitis; TCMR, T cell–mediated rejection.