TABLE 3.
Top genes (sorted by P value) selectively increased in biopsies with TCMR, AMR, recent injury, and atrophy-fibrosis
| TCMR | AMR | New/recent injury (IRRATs) | Atrophy-fibrosis | ||||
|---|---|---|---|---|---|---|---|
| Gene name | Gene Symbol | Gene name | Gene Symbol | Gene name | Gene Symbol | Gene name | Gene Symbol |
| ADAM-like, decysin 1 | ADAMDEC1 | Phospholipase A1 member A | PLA1A | Secretory leukocyte peptidase inhibitor | SLPI | Carboxypeptidase A3 (mast cell) | CPA3 |
| Chemokine (C-X-C motif) ligand 13 | CXCL13 | Fibroblast growth factor binding protein 2 | FGFBP2 | Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | SERPINA3 | Chemokine (C-X-C motif) ligand 6 | CXCL6 |
| Signal-regulatory protein gamma | SIRPG | Granulysin | GNLY | Early growth response 1 | EGR1 | Membrane-spanning 4-domains, subfamily A, member 2 (FCER1B) | MS4A2 |
| Janus kinase and microtubule interacting protein 1 | JAKMIP1 | SH2 domain containing 1B | SH2D1B | Olfactomedin 4 | OLFM4 | Gamma-aminobutyric acid A receptor, pi | GABRP |
| Inducible T-cell co-stimulator | ICOS | Sphingosine-1-phosphate receptor 5 | S1PR5 | Pentraxin 3, long | PTX3 | tryptase alpha/beta 1 | TPSAB1 |
| Chemokine (C-X-C motif) receptor 6 | CXCR6 | Chemokine (C-X-C motif) ligand 11 | CXCL11 | Cathepsin S | CTSS | Fc Epsilon Receptor Ia | FCER1A |
| Zinc finger, BED-type containing 2 | ZBED2 | LY6 | LYPD5 | retinoic acid receptor responder (tazarotene induced) 1 | RARRES1 | Ceruloplasmin (ferroxidase) | CP |
| Cytotoxic T-lymphocyte-associated protein 4 | CTLA4 | T cell receptor delta constant | TRDC | lactotransferrin | LTF | Calpain 8 | CAPN8 |
| Interferon gamma | IFNG | Killer cell lectin-like receptor subfamily F, member 1 | KLRF1 | A kinase (PRKA) anchor protein 12 | AKAP12 | Cyclin D2 | CCND2 |
| Lymphocyte-activation gene 3 | LAG3 | Chemokine (C-C motif) ligand 4 | CCL4 | Peptidase inhibitor 15 | PI15 | Transmembrane protease, serine 4 | TMPRSS4 |
| SH2 domain containing 1A | SH2D1A | Guanylate binding protein 4 | GBP4 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | ADAMTS1 | Annexin A1 | ANXA1 |
| Basic leucine zipper transcription factor, ATF-like | BATF | Roundabout, axon guidance receptor, homolog 4 (Drosophila) | ROBO4 | Multiple EGF-like-domains 11 | MEGF11 | Anterior gradient 3, protein disulfide isomerase family member | AGR3 |
| B and T lymphocyte associated | BTLA | Chemokine (C-X3-C motif) receptor 1 | CX3CR1 | Oncostatin M receptor | OSMR | Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | CXCL1 |
| CD8a molecule | CD8A | Perforin 1 (pore forming protein) | PRF1 | Protein tyrosine phosphatase, receptor type, C | PTPRC | Frizzled-related protein | FRZB |
| CD8b molecule | CD8B | CD160 molecule | CD160 | Ecotropic viral integration site 2A | EVI2A | Immunoglobulin kappa variable 1-27 | IGKV1-27 |
| T cell immunoreceptor with Ig and ITIM domains | TIGIT | Indoleamine 2,3-dioxygenase 1 | IDO1 | Transmembrane protein 252 | TMEM252 | Immunoglobulin heavy locus | IGH |
| Protein tyrosine phosphatase, nonreceptor type 7 | PTPN7 | Killer cell lectin-like receptor subfamily D, member 1 | KLRD1 | FBJ murine osteosarcoma viral oncogene homolog | FOS | Immunoglobulin kappa constant | IGKC |
| TOX high mobility group box family member 2 | TOX2 | Chemokine (C-X-C motif) ligand 9 | CXCL9 | Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | ITGB3 | Immunoglobulin kappa locus | IGK |
| Src-like-adaptor 2 | SLA2 | Tryptophanyl-tRNA synthetase | WARS | Nicotinamide N-methyltransferase | NNMT | Tissue factor pathway inhibitor 2 | TFPI2 |
| SP140 nuclear body protein | SP140 | Chemokine (C-X-C motif) ligand 10 | CXCL10 | Versican | VCAN | Annexin A1 | ANXA1 |
AMR, antibody-mediated rejection; Ig, immunoglobulin; IRRAT, injury- and rejection-associated transcript; TCMR, T cell–mediated rejection.