TABLE 4.

Selected IPA pathways associated with molecular TCMR and AMR^79,81

TCMR		AMR
Pathway term name	Adjusted P	Pathway term name	Adjusted P
CTLA4 signaling in cytotoxic T lymphocytes (96)	1.9 × 10−7	Natural killer cell signaling	3.6 × 10−6
T cell receptor signaling (109)	1.9 × 10−7	Fc epsilon RI signaling	2.1 × 10−3
T helper cell differentiation (72)	5.5 × 10−7	Granulocyte adhesion and diapedesis	3.6 × 10−6
Communication between innate and adaptive immune cells (112)	6.6 × 10−5	Agranulocute adhesion and diapedesis	5.0 × 10−6
Primary immunodeficiency signaling (64)	1.4 × 10−4	Angiopoietin signaling	1.2 × 10−3
CD28 signaling in T helper cells (126)	8.1 × 10−4	Caveolar-mediated endocytosis signaling	2.0 × 10−3
Role of NFAT in regulation of the immune response (200)	1.4 × 10−3	eNOS signaling	5.2 × 10−3
iCOS-iCOSL signaling in T helper cells (126)	1.5 × 10−3	Coagulation system	5.6 × 10−3
Type I diabetes mellitus signaling (121)	1.5 × 10−3	Nitric oxide signaling in the cardiovascular system	6.8 × 10−3
PKCθ signaling in T lymphocytes (144)	1.6 × 10−3	VEGF family ligand-receptor interactions	1.0 × 10−2

AMR, antibody-mediated rejection; TCMR, T cell–mediated rejection.