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. 2023 Oct 17;14(12):2535–2563. doi: 10.1039/d3md00560g

FDA-approved drugs containing indole structures.

Compd. Names Activity Targets or mechanisms
1 Osimertinib Anti-tumor Mutant-selective EGFR inhibitor
2 VCR Anti-tumor Tubulin inhibitor
3 Reserpine Anti-hypertensive Blocking the transmission of sympathetic impulses
4 Tadalafil Anti-pulmonary hypertension Phosphodiesterase inhibitor
5 Fluvastatin Hypolipidemic Inhibition of endogenous cholesterol synthesis
6 Indomethacin Anti-inflammatory Cyclooxygenase inhibitor
7 Zafirlukast Anti-asthma Leukotriene receptor antagonist
8 Delavirdine Anti-HIV Reverse transcriptase inhibitor