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. 2023 Oct 17;14(12):2535–2563. doi: 10.1039/d3md00560g

Biological activity of quinone-indole derivatives 122–124.

Compd. Activity Ref.
122 SiIHa cells: IC50 = 3.2 μM 177
CaLo cells: IC50 = 2.69 μM
C33-A cells: IC50 = 0.0034 μM
123 A578 cells: IC50 = 5 nM 178
Shikonin A578 cells: IC50 = 0.46 μM 178
124 MCF-7 cells: IC50 = 11.33 μM 181
HepG2 cells: IC50 = 10.14 μM
MG-63 cells: IC50 = 13.85 μM
Naphthoquinone MCF-7 cells: IC50 = 16.92 μM 181
HepG2 cells: IC50 = 15.89 μM
MG-63 cells: IC50 > 25 μM