Biological activity of quinone-indole derivatives 122–124.
Compd. | Activity | Ref. |
---|---|---|
122 | SiIHa cells: IC50 = 3.2 μM | 177 |
CaLo cells: IC50 = 2.69 μM | ||
C33-A cells: IC50 = 0.0034 μM | ||
123 | A578 cells: IC50 = 5 nM | 178 |
Shikonin | A578 cells: IC50 = 0.46 μM | 178 |
124 | MCF-7 cells: IC50 = 11.33 μM | 181 |
HepG2 cells: IC50 = 10.14 μM | ||
MG-63 cells: IC50 = 13.85 μM | ||
Naphthoquinone | MCF-7 cells: IC50 = 16.92 μM | 181 |
HepG2 cells: IC50 = 15.89 μM | ||
MG-63 cells: IC50 > 25 μM |