Biological activity of podophyllotoxin-indole derivatives 37–42.

Compd.	Activity	Ref.
37	HepG2 cells: IC50 = 0. 1 μM	60
	HeLa cells: IC50 = 0.08 μM
	A549 cells: IC50 = 0.08 μM
	MCF-7 cells: IC50 = 0.07 μM
Podophyllotoxin	HepG2 cells: IC50 = 2.4 μM	60
	HeLa cells: IC50 = 6.9 μM
	A549 cells: IC50 = 2.6 μM
	MCF-7 cells: IC50 = 2.4 μM
Colchicine	HepG2 cells: IC50 = 5.8 μM	60
	HeLa cells: IC50 = 10.2 μM
	A549 cells: IC50 = 9.7 μM
	MCF-7 cells: IC50 = 14.3 μM
38	HepG2 cells: IC50 = 1.93 μM	61
	HeLa cells: IC50 = 2.2 μM
Podophyllotoxin	HepG2 cells: IC50 = 6.21 μM	61
	HeLa cells: IC50 = 9.32 μM
39	A549 cells: IC50 = 1.87 μM	62
40	A549 cells: IC50 = 2.24 μM	62
Podophyllotoxin	A549 cells: IC50 = 3.76 μM	62
VP-16	A549 cells: IC50 = 2.27 μM	62
41	K562 cells: IC50 = 0.1 μM	63
42	K562 cells: IC50 = 0.034 μM	64
VP-16	K562 cells: IC50 = 0.764 μM	64
VCR	K562 cells: IC50 = 0.178 μM	64