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. 2023 Oct 17;14(12):2535–2563. doi: 10.1039/d3md00560g

Biological activity of coumarin-indole derivatives 50–55.

Compd. Activity Ref.
50 MCF-7 cells: IC50 = 7.4 μM 79
51 MCF-7 cells: IC50 = 8.01 μM 80
52 MCF-7 cells: IC50 = 17.5 μM 81
53 HOP-92 cells: GI50 = 0.95 μM 82
54 MRSA: MIC = 0.25 μg mL−1 83
E. faecalis: MIC = 0.25 μg mL−1
S. aureus ATCC 25922: MIC = 0.25 μg mL−1
S. aureus ATCC 29213: MIC = 0.25 μg mL−1
E. coli: MIC = 0.25 μg mL−1
A. baumannii: MIC = 0.25 μg mL−1
Norfloxacin MRSA: MIC = 4 μg mL−1 83
E. faecalis: MIC = 4 μg mL−1
S. aureus ATCC 25922: MIC = 4 μg mL−1
S. aureus ATCC 29213: MIC = 2 μg mL−1
E. coli: MIC = 2 μg mL−1
A. baumannii: MIC = 4 μg mL−1
55 M. tuberculosis H37Rv strain: MIC = 2.02 μM 84