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. 2023 Oct 17;14(12):2535–2563. doi: 10.1039/d3md00560g

Biological activity of coumarin-indole derivatives 56–60.

Compd. Activity Ref.
56 Anti-Leishmania activity: IC50 = 95.5 μg mL−1 85
DPPH: IC50 = 12.4 μM
57 Anti-Leishmania activity: IC50 = 95 μg mL−1 85
DPPH: IC50 = 13.49 μM
Sodium stibogluconate Anti-Leishmania activity: IC50 = 490 μg mL−1 85
Sodium ascorbate DPPH: IC50 = 12.8 μM 85
58 α-Glucosidase: IC50 = 85 μM 86
Acarbose α-Glucosidase: IC50 = 750 μM 86
59 HMG-CoA reductase: inhibition rate = 56% 87
60 Acetylcholinesterase: IC50 = 0.16 μM 88
61 HepG2 cells: IC50 = 4.63 μM 89
SMMC-7721 cells: IC50 = 3.11 μM