Biological activity of coumarin-indole derivatives 56–60.
Compd. | Activity | Ref. |
---|---|---|
56 | Anti-Leishmania activity: IC50 = 95.5 μg mL−1 | 85 |
DPPH: IC50 = 12.4 μM | ||
57 | Anti-Leishmania activity: IC50 = 95 μg mL−1 | 85 |
DPPH: IC50 = 13.49 μM | ||
Sodium stibogluconate | Anti-Leishmania activity: IC50 = 490 μg mL−1 | 85 |
Sodium ascorbate | DPPH: IC50 = 12.8 μM | 85 |
58 | α-Glucosidase: IC50 = 85 μM | 86 |
Acarbose | α-Glucosidase: IC50 = 750 μM | 86 |
59 | HMG-CoA reductase: inhibition rate = 56% | 87 |
60 | Acetylcholinesterase: IC50 = 0.16 μM | 88 |
61 | HepG2 cells: IC50 = 4.63 μM | 89 |
SMMC-7721 cells: IC50 = 3.11 μM |