Table 3.
Ongoing clinical trials recruiting adenocarcinoma patients for CSC-based trials (source: clinicaltrials.gov; retrieved 20 May 2023).
| Serial no. | Conditions | Interventions | Trial number |
|---|---|---|---|
| 1 | Gastric and cardia adenocarcinomas | Procedure: biopsy | NCT02491840 |
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| 2 | Pancreas cancer | Drug: bethanechol | NCT03572283 |
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| 3 | Resectable pancreatic adenocarcinoma | Drug: HIPEC-gemcitabine | NCT03251365 |
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| 4 | Adenocarcinoma of lung | Genetic: MSCTRAIL|Drug: placebo | NCT03298763 |
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| 5 | Pancreatic adenocarcinoma metastatic|BRCA1 mutation|BRCA2 mutation|Pancreatic acinar cell carcinoma|Pancreatic ductal adenocarcinoma|Pancreatic cancer|Metastatic pancreatic cancer|Metastatic pancreatic ductal adenocarcinoma|Breast cancer metastatic|Breast cancer stage IV|Pancreatic cancer stage IV|HER2-negative breast cancer|HER2 negative breast carcinoma|Adenocarcinoma of the breast|PALB2 gene mutation | Drug: melphalan|Drug: BCNU|Drug: vitamin B12B|Drug: vitamin C|Drug: ethanol|Device: autologous hematopoietic stem cells | NCT04150042 |
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| 6 | Fallopian tube clear cell adenocarcinoma|Fallopian tube endometrioid adenocarcinoma|Fallopian tube mucinous adenocarcinoma|Fallopian tube serous adenocarcinoma|Fallopian tube transitional cell carcinoma|Fallopian tube undifferentiated carcinoma|Malignant ovarian brenner tumor|Ovarian clear cell adenocarcinoma|Ovarian endometrioid adenocarcinoma|Ovarian mucinous adenocarcinoma|Ovarian seromucinous carcinoma|Ovarian serous adenocarcinoma|Ovarian transitional cell carcinoma|Ovarian undifferentiated carcinoma|Primary peritoneal serous adenocarcinoma|Recurrent fallopian tube carcinoma|Recurrent ovarian carcinoma|Recurrent primary peritoneal carcinoma | Other: laboratory biomarker analysis|Procedure: mesenchymal stem cell transplantation|Biological: oncolytic measles virus encoding thyroidal sodium iodide symporter | NCT02068794 |
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| 7 | Pancreatic ductal adenocarcinoma|Metastatic pancreatic cancer|Circulating tumor cell | Other: detection of circulating tumor cells expressing Axl: CTC-AXL(+) | NCT05346536 |
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| 8 | Pancreatic cancer|Metastatic pancreatic cancer|Metastatic pancreatic adenocarcinoma | Drug: zolbetuximab|Drug: nab-paclitaxel|Drug: gemcitabine | NCT03816163 |
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| 9 | Colorectal cancer metastases and hepatocellular carcinomas | Procedure: tumor /metastases removal | NCT05384184 |
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| 10 | Rectum adenocarcinoma | Other: biopsy | NCT02849158 |
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| 11 | Central nervous system nongerminomatous germ cell tumor|Choriocarcinoma|Embryonal carcinoma|Immature teratoma|Malignant teratoma|Mixed germ cell tumor|Pineal region germ cell tumor|Pineal region immature teratoma|Pineal region yolk sac tumor|Suprasellar germ cell tumor | Drug: carboplatin|Drug: etoposide|Biological: filgrastim|Drug: ifosfamide|Drug: mesna|Biological: pegfilgrastim|Procedure: peripheral blood stem cell transplantation|Other: questionnaire administration|Radiation: radiation therapy|Procedure: second-look surgery|Drug: thiotepa | NCT04684368 |
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| 12 | Hepatocellular carcinoma | Drug: peginterferon α-2b (pegabin) with entecavir or tenofovir fumarate or propofol tenofovir fumarate | Procedure: radical surgery | NCT05466565 |