Skip to main content
. Author manuscript; available in PMC: 2024 Apr 1.
Published in final edited form as: Thromb Haemost. 2022 Dec 6;123(4):380–392. doi: 10.1055/a-1993-4193

Fig. 1. Cartoon models highlighting FXIII locations and activation strategies.

Fig. 1

pFXIII undergoes proteolytic activation by thrombin to form active FXIII-A* in which AP is removed and AP cleft is exposed. cFXIII is expressed in a variety of cells including platelets, monocytes, macrophages, chondrocytes, osteoblasts and preadipocytes. cFXIII undergoes nonproteolytic activation to form FXIII-A° in which AP is still associated with A subunit. In resting platelets and monocytes, FXIII is of cytoplasmic localization, however upon activation of these cells, FXIII-A is exposed on the surface of these cells. Cartoon model is created with BioRender.com.