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. 2023 Dec 7;29(12):3184–3192. doi: 10.1038/s41591-023-02653-5

Table 1.

Demographics for cohorts in the meta-analysis of PAU

Cohorts Traits Ncase Ncontrol Ntotal Nfemale (%) Neffective Ref. a
EUR ancestry
MVP AUD 80,028 368,113 448,141 33,345 (7.4) 262,947 9 and new
FinnGen AUD 8,866 209,926 218,792 123,579 (56.5) 34,027 Newb
UKB–EUR1 AUDIT–P – – 132,001 74,113 (56.1) 132,001 9 and new
UKB–EUR2 AUDIT–P – – 17,898 10,529 (58.5) 17,898 New
PGC AD 9,938 30,992 40,930 20,933 (51.1) 23,075 8d
QIMR AGDS AD 6,726 4,467 11,193 8,605 (76.9) 10,737 New
QIMR TWINS AD 2,772 5,630 8,402 4,922 (58.6) 7,430 8 and new
QIMR GBP AD 1,287 751 2,038 1,435 (70.4) 1,897 New
iPSYCH1 AD 2,117 13,238 15,355 8,077 (52.6) 7,301 New
iPSYCH2 AD 1,024 5,732 6,756 3,607 (53.4) 3,475 New
YP3 AD 567 1,074 1,641 854 (52.0) 1,484 New
Subtotal PAU 113,325 639,923 903,147 289,999 (32.1) 502,272
AFR ancestry
MVP AUD 36,330 79,100 115,430 16,084 (13.9) 99,583 10 and new
PGC AD 3,335 2,945 6,280 3,124 (49.7) 4,991 8
YP3 AD 451 410 861 430 (50.0) 959 New
Subtotal AUD 40,116 82,455 122,571 19,638 (16.0) 105,433
LA
MVP AUD 10,150 28,812 38,962 3,731 (9.6) 30,023 10 and new
EASa ancestry
MVP AUD 701 6,254 6,955 747 (10.7) 2,521 26
Han Chinese–GSA AD 533 2,848 3,381 1,012 (29.9) 1,796
Thai METH–MEGA AD 794 1,576 2,370 1,008 (42.5) 2,112
Thai METH–GSA AD 127 405 532 263 (49.4) 387
Han Chinese–Cyto AD 99 214 313 0 (0) 271
Subtotal AUD 2,254 11,297 13,551 3,030 (22.4) 7,087
SAS ancestry
MVP AUD 107 389 496 67 (13.5) 336 10 and new
UKB–SAS AUDIT–P – – 1,220 535 (43.9) 1,220 New
Subtotal PAU 107 389 1,716 602 (35.1) 1,556
Total PAU 165,952 762,876 1,079,947 317,000 (29.4) 646,371

Note:

aData either published in previous alcohol GWAS or newly included for this project.

bFinnGen summary statistics were downloaded from FinnGen data freeze v5 (https://r5.finngen.fi/).

cIncluded related individuals from UKB.

dReran the PGC AD GWAS in EUR excluding two Australian cohorts.

Cohorts are described in the Methods. UKB–EUR1: genetically defined EUR ancestry White-British by UKB; UKB–EUR2: genetically defined EUR non-White-British participants (Methods); AGDS, the Australian Genetics of Depression Study; TWINS, the Australian twin family study of AUD; GBP, the Australian Genetics of Bipolar Disorder Study; iPSYCH1, phase 1 of iPSYCH; iPSYCH2, phase 2 of iPSYCH; YP3, Yale–Penn 3; Neffective, effective sample size; MEGA, Illumina Multi-Ethnic Global Array.