Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Dec 8;29(12):3149–3161. doi: 10.1038/s41591-023-02644-6

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a,b, Representative MR T2-weighted axial (a, left panel in b) and T1-weighted sagittal (right panel in b) images obtained in patients with a solitary CCM lesion (yellow arrows) in the temporal (a) or frontal lobe (b). Preoperative images (at higher magnification a′) show typical ‘popcorn’ appearance of single CCM. Postoperative follow-up MRI (a′ at higher magnification) without evidence of residual CCM confirms complete excision. White arrows (1–4 in b) point to the trajectory via which specimens were obtained. c, Intraoperative real-time image sequence showing the microscopic views of specimens sourced at corresponding position (1–4 in b). d, Representative images of GFAP immunoreactivity in regions 1–4. e,f, Note the manifestation of morphological changes in GFAP⁺ astrocytes (e) and IBA1⁺ microglia (f) with distance to the CCM core (as indicated by 1–4). Scale bars: 100 µm (d) and 20 µm (e and f).