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. 2023 Dec 13;624(7991):390–402. doi: 10.1038/s41586-023-06819-6

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© The Author(s) 2023, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — a. Stacked bar plots representing the breakdown of human boundaries for each indicated group for level 0 and level 1 conservation. b. Level 2 conservation of human boundaries showing the overlap between each species for the same cell type (outer circle stacked bars). Inner circles showing the breakdown for mammal and primate comparisons for all human boundaries. c. Heatmaps for each species showing the scaled percentage overlap of peaks and loops across cell types. d. Barplot showing the percent of loops with a TSS overlapping at least one anchor bin. *** p < 2e-16 from Fisher’s exact test compared to mammal level 0, except primate level 1 and 2 were compared to primate level 0. e. Barplot showing the percent of loops with a boundary overlapping at least one anchor bin. P-values same as in d. f. Boxplots of anchor to anchor distance for loops of indicated conservation level. *** p < 2e-16 from two-sided, unpaired Wilcoxon rank sum. Box plots encompass 25th to 75th percentiles; central lines represent medians; whiskers represent 1.5 times the interquartile interval. Sample sizes reported in Supplementary Table 34. Species silhouettes in a and b created in BioRender.