Table 4.
All hematological malignancies | Lymphoid malignancies | Myeloid malignancies | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
# | ERR /100 mGy | 95% CI | # | ERR /100 mGy | 95% CI | # | ERR /100 mGy | 95% CI | ||||
Main results1 | 790 | 1.96 | 1.10 | 3.12 | 578 | 2.01 | 1.02 | 3.42 | 203 | 2.02 | 0.47 | 4.77 |
Potential confounders analysis: | ||||||||||||
No adjustment for birth cohort | ||||||||||||
790 | 1.92 | 1.08 | 3.05 | 578 | 1.99 | 1.02 | 3.37 | 203 | 1.92 | 0.43 | 4.53 | |
a) SES2 | ||||||||||||
Unadjusted | 210 | 1.40 | 0.08 | 3.83 | 161 | 0.99 | −0.16 | 3.37 | 47 | 4.22 | −0.17 | 30.6 |
Adjusted | 210 | 1.44 | 0.10 | 3.90 | 161 | 1.03 | −0.15 | 3.45 | 47 | 4.16 | −0.17 | 29.6 |
Effect modification analysis: | ||||||||||||
a) Sex | ||||||||||||
Males | 466 | 1.45 | 0.55 | 2.80 | 343 | 1.91 | 0.71 | 3.85 | 118 | 0.65 | -0.42 | 2.89 |
Females | 324 | 2.82 | 1.27 | 5.32 | 235 | 2.14 | 0.71 | 4.64 | 85 | 6.09 | 1.62 | 19.1 |
Het. P value | 0.20 | 0.85 | 0.03 | |||||||||
b) Age at exposure category (note: one individual can enter in more than one category if they had several CTs) | ||||||||||||
<5 | 219 | 0.78 | 0.06 | 1.78 | 165 | 0.74 | −0.05 | 1.93 | 52 | 1.12 | −0.29 | 3.60 |
5 to <10 | 156 | 1.81 | 0.57 | 3.39 | 115 | 1.87 | 0.48 | 3.74 | 40 | 1.72 | −0.71 | 5.41 |
10+ | 466 | 4.02 | 2.48 | 5.99 | 336 | 4.25 | 2.41 | 6.71 | 124 | 3.48 | 1.05 | 7.35 |
Het. P value | 0.001 | 0.002 | 0.32 | |||||||||
c) Time since exposure (years) (note: one individual can enter in more than one category if they had several CTs) | ||||||||||||
2 to <5 | 303 | 3.56 | 1.96 | 5.57 | 222 | 3.09 | 1.37 | 5.37 | 76 | 4.88 | 1.66 | 9.87 |
5 to <10 | 291 | 2.82 | 1.58 | 4.33 | 216 | 2.90 | 1.46 | 4.70 | 74 | 2.98 | 0.66 | 6.40 |
10+ | 260 | 1.24 | 0.42 | 2.29 | 184 | 1.46 | 0.49 | 2.75 | 72 | 0.45 | −0.80 | 2.56 |
Het. P value | 0.07 | 0.21 | 0.04 |
1Stratified on sex, birth cohort and country—attained age is used as the underlying time variable.
2Analysis restricted to countries where SES data were available: Belgium, France, the Netherlands and Spain.
#, number of cases; Het., heterogeneity.