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. 2023 Nov 23;29(12):3233–3242. doi: 10.1038/s41591-023-02645-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — Trophoblast and embryoblast lineages develop at day 6, hypoblast and epiblast develop from the embryoblast at day 8, hypoblast develops into the yolk sac, while epiblast develops into the different embryonic germ layers and the embryo and into the amnionic cavity. Extraembryonic mesoderm develops around day 11 from the hypo- and epiblast. The trophoblast cells become the placenta including cytotrophoblast, intermediate trophoblast, and syncytiotrophoblast cells, chorionic villi develop around day 13 from the trophoblast lineage (see also Fig. 2a).