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. 2023 Nov 23;29(12):3233–3242. doi: 10.1038/s41591-023-02645-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Segregational origin of each individual aberration in both extra-embryonic mesoderm (EM) and chorionic villi (CV) tissue per POC detected by genome haplarithmisis, whereas samples with aberrations of mitotic origin (n = 34: 17 EM and 17 CV) or meiotic origin with greater than 10% mosaicism difference between EM and CV (n = 4: two EM and two CV) were selected for EM/CV plots and mosaicism statistics. The mosaicism degree in EM samples (n = 19) was significantly higher than that in CV samples (n = 19) (two-sided Wilcoxon signed-rank test). The box plot represents the 25th percentile, median and 75th percentile, respectively, whereas the whiskers extend to the farthest data point that is no more than 1.5 times the interquartile range (IQR) from the upper or lower quartile. ND, not determined.