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. 2023 Nov 23;29(12):3233–3242. doi: 10.1038/s41591-023-02645-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — a, Heatmap of EPIC array SNP probes (n = 59) of all paired EM and CV tissue samples (n = 13). Hierarchical clustering of the samples was constructed using Euclidian distance and complete linkage and is shown as a dendrogram. b, Scatter plot showing the projection of all EM and CV tissue samples (n = 13) into the principal component space generated using reference data for sex prediction (not shown). All chosen samples were female according to the haplotyping analysis and the methylation sex prediction. Grey dashed lines separate the quadrants where male (XY) samples are expected to map to the lower left quadrant and female (XX) samples to the upper right quadrant.