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. 2023 Dec 13;6:1265. doi: 10.1038/s42003-023-05626-z

Fig. 4. Krt5+ progenitor cell proliferation was induced in Flu infected K18 mice but not in SARS-CoV-2-infected K18 mice at 7, 14, and 21 DPI.

Fig. 4

a SMA-Krt5 double staining shows proliferation of Krt5+ cells in consolidated regions of Flu-infected lungs at 7 (n = 3), 14 (n = 4) and 21 DPI (n = 5). In SARS-CoV-2 infected lungs, consolidated pulmonary regions do not exhibit proliferation of Krt5+ cells (red) at 7 (n = 3), 14 (n = 3), or 21 DPI (n = 3). Comparison of the expression of SMA (b) and Krt5 (c) in regions of consolidated and normal lungs from the same animal as detailed in Supplementary Fig. 9. d Number of pulmonary regions with proliferation of Krt5+ cells (“pods”) per lung section. Data are shown as mean ± SEM. To compare values obtained from two groups, two-tailed unpaired Student’s t test was performed. ** indicates p < 0.01. * indicates p < 0.05.