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. 2023 Dec 13;6:1265. doi: 10.1038/s42003-023-05626-z

Fig. 7. scRNA-seq analysis of Flu-infected and SARS-CoV-2-infected lungs.

Fig. 7

a Major clusters and respective cell types for Flu and SARS-CoV-2 tissues at 4 DPI by scRNA-seq data. Uniform manifold approximation and projection (UMAP) for dimension reduction plot with major cell types of scRNA-seq. Single-cell suspensions from whole infected lungs at 4 DPI for both SARS-CoV-2 and Flu were processed and sequenced. The 8146 cells identified after being combined and processed, we identified ten major clusters including C1qa+ monocyte (n = 2,482), Endothelial (n = 1637), T cells (n = 892), Fibroblast (n = 804), S100a8+ monocyte (n = 633), Plasma (n = 280), NK cells (n = 258), Club (n = 220), and Epithelial (n = 207). b–e Expression of Ifit1, Ifit2, Ifit3, and Cxcl10 in the Fu-infected and SARS-CoV-2-infected lungs.