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. 2023 Dec 14;13:22187. doi: 10.1038/s41598-023-49310-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Gene expression profiles after pilocarpine-induced SE follow a time-dependent pattern. (A) Principal component analysis (PCA) of control (Ctr) and pilocarpine-induced status epilepticus (SE) samples for each time point (Ctr: 12 h, 36 h and 72 h; SE: 6 h, 12 h, 24 h, 36 h, and 72 h; n = 3 each). (B,C) Venn diagrams representing the number of differentially expressed genes between (B) SE and control samples (p ≤ 0.05; Log2FC ≥ |0.66|), and (C) all SE samples (p ≤ 0.05; Log2FC ≥ |0.66|). (D) Heat map of the 100 most differently expressed genes categorized according to their mRNA increase (upregulated clusters A–E; upper panel) or decrease (downregulated clusters F–I; lower panel) analysed by k-means clustering.