Table 2.
Clinical details during the pediatric intensive care unit stay by DoC status
| n (%) or median (interquartile range) |
Overall (n=401) |
No DoC (n = 330) |
DoC (n = 71) |
p e |
|---|---|---|---|---|
| Organ Support | ||||
| ECMO | 30 (7.5) | 22 (6.7) | 8 (11.3) | 0.211b |
| Duration (days) | 10.0 (6.0-14.0) | 11.0 (6.0-15.0) | 7.5 (3.0-9.5) | 0.080 a |
| Mechanically ventilated | 363 (90.5) | 293 (88.8) | 70 (98.6) | 0.007 b |
| Duration (days) | 9 (6.0-16.0) | 9 (6.0-16.0) | 9 (6.0-17.0) | 0.989 a |
| CRRT | 51 (12.7) | 36 (10.9) | 15 (21.1) | 0.029 b |
| Duration (days) | 8.0 (5.0-15.0) | 7.5 (4.0-15.0) | 9.0 (5.0-14.0) | 0.747 a |
| Nitric Oxide | 92 (22.9) | 77 (23.3) | 15 (21.1) | 0.757 b |
| Duration (days) | 5 (3.0-9.0) | 5 (3.0-9.0) | 5 (2.0-12.0) | 0.975 a |
| Infections at Eligibility | ||||
| Bacterial | 341 (85.0) | 274 (83.0) | 67 (94.4) | 0.016 b |
| Viral | 197 (49.1) | 178 (53.9) | 19 (26.8) | <0.001 b |
| Fungal | 20 (5.0) | 13 (3.9) | 7 (9.9) | 0.064b |
| Protozoal | 3 (0.8) | 3 (0.9) | 0 (0.0) | 1.000 b |
| Outcomes | ||||
| ICU Length of Stay,days | 12 (7.0-20.0) | 12 (6.0-20.0) | 12 (7.0-25.0) | 0.453 a |
| ICU Mortality | 44 (11.0) | 30 (9.1) | 14 (19.7) | 0.019 b |
| Hospital Length of Stay,days | 19 (11.0-35.0) | 19 (11.0-35.0) | 21 (12.0-38.0) | 0.833 a |
| Hospital Mortality | 48 (12.0) | 33 (10.0) | 15 (21.1) | 0.011 b |
| Organ Failure Category | ||||
| Single Organ Failure | 100 (24.9) | 95 (28.8) | 5 (7.0) | <0.001 b |
| Multiple Organ Failure | 301 (75.1) | 235 (71.2) | 66 (93.0) | <0.001 b |
| MOF, no Phenotype | 200 (49.9) | 163 (49.4) | 37 (52.1) | 0.697 b |
| MOF, IPMOF | 85 (21.2) | 61 (18.5) | 24 (33.8) | 0.006 b |
| MOF, TAMOF | 37 (9.2) | 26 (7.9) | 11 (15.5) | 0.067 b |
| MOF, SMOF | 7 (1.8) | 4 (1.2) | 3 (4.2) | 0.109 b |
| MOF, 2+ Phenotypes | 25 (6.2) | 18 (5.5) | 7 (9.9) | 0.176 b |
| Macrophage Activation Syndrome | 24 (6.0) | 14 (4.2) | 10 (14.1) | 0.004 b |
| Lab values | ||||
| Ferritinc, ng/mlc | 260.0 (121.0-741.0) | 237.5 (121.5-672.3) | 349.0 (118.0-1193.6) | 0.098 a |
| C-reactive proteinc, mg/dlc | 11.1 (4.2-20.0) | 10.9 (4.0-19.4) | 11.6 (5.5-21.6) | 0.214 a |
| sFAS ligandc, pg/mlc | 54.7 (34.9-85.4) | 55.3 (36.4-85.8) | 53.4 (32.9-84.4) | 0.387 a |
| TNF-alphad, pg/mld | 321.1 (73.3-800.9) | 341.0 (78.2-818.6) | 250.8 (57.1-653.2) | 0.442 a |
a
Wilcoxon Rank-Sum Test
b
Fisher’s Exact Test
c
Maximum throughout PICU stay
d
Minimum whole blood ex vivo lipopolysaccharide-stimulated TNF-alpha values throughout PICU stay
e
No adjustments for multiple comparisons
DoC, Disorders of Consciousness; ECMO, Extracorporeal membrane oxygenation; CRRT, Continuous Renal Replacement Therapy; SFAS, soluble FAS ligand; TNF, tumor necrosis factor; ICU, intensive care unit; MOF, Multiple Organ Failure; IPMOF, Immunoparalysis Associated Multiple Organ Failure; TAMOF, Thrombocytopenia Associated Multiple Organ Failure; SMOF, Sequential Liver Failure Associated Multiple Organ Failure