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. 2023 Oct 19;16(12):2591–2603. doi: 10.1111/cts.13653

TABLE 4.

ANOVA p‐values for dacomitinib and Vizimpro®.

Parameter Fasting condition Fed condition
lnCmax lnAUC0–t lnAUC0–∞ lnCmax lnAUC0–t lnAUC0–∞
Sequence 0.9618 0.7303 0.8402 0.1065 0.0956 0.0904
Period 0.5010 0.1940 0.2702 0.1261 <0.0001 <0.0001
Formulation 0.2403 0.0606 0.0842 0.9994 0.8757 0.7700
Subject*sequence 0.0002 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001

Abbreviations: AUC0–t , area under the concentration–time curve from time 0 to the last observed non‐zero concentration calculated by the linear trapezoidal method; AUC0–∞, area under the concentration–time curve from time 0 extrapolated to infinity; Cmax, maximum plasma concentration.