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. 2023 Oct 23;16(12):2494–2506. doi: 10.1111/cts.13624

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© 2023 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Log₂ fold‐change of AZD9567 or prednisolone versus dexamethasone for differentially expressed genes common to prednisolone and dexamethasone (preclinical study). AZD9567 (blue) or prednisolone (red) effects compared with dexamethasone (highest concentration, respectively) for all differentially expressed genes (false discovery rate < 0.05) common to prednisolone and dexamethasone treatments in primary human monocytes stimulated with TNFα, at 4 h. DMSO, dimethyl sulfoxide; TNFα, tumor necrosis factor α.