TABLE 2.
Pharmacokinetic parameters of AZD9567.
| Parameter | Summary statistic | AZD9567 (n = 11) | Prednisolone (n = 10) |
|---|---|---|---|
| AUC(0–6 h) (h·nmol/L) | Geometric mean (CV%) | 17,740 (35) | 3591 (22) |
| T max (h) | Median (min, max) | 0.7 (0.3, 1.0) | 1.5 (1.0, 1.5) |
| C max (nmol/L) | Geometric mean (CV%) | 4468 (27) | 980 (26) |
| C trough (nmol/L) | Geometric mean (CV%) | 382 (96) | 8 (102) |
Abbreviations: AUC(0–6 h), area under the concentration–time curve from time zero to 6 h after dose; C max, maximum observed concentration; C trough, observed trough plasma concentration; CV, coefficient of variation; T max, time to maximum observed concentration.