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Effect of iptacopan on biomarkers. Arithmetic mean ± SE, serum C3 (a), serum Wieslab activity (b), plasma sC5b9 (c), creatinine normalized urine sC5b9 (d), plasma Bb (e). Values below LLOQ are imputed as LLOQ/2 and values above ULOQ are imputed as ULOQ for the analysis. Baseline visit is defined to be the baseline 1 visit assessment (day −30). ∗Baseline is defined as day 1 predose assessment. LLOQ, lower limit of quantification; SE, standard error; ULOQ, upper limit of quantification.
