Table 2.
Compairsons between the pre-TF2 and TF2 cohorts
| All patients who received CRRT (N = 178) | ||||
|---|---|---|---|---|
| Variable | Pre-TF2 (n = 71) | Post-TF2 (n = 107) | P-value | |
| Pre-CRRT patient demographics and fluid status | ||||
| Patient age (yrs) | Median [IQR] | 8.1 [2.0, 15.1] | 10.3 [2.3, 17.0] | 0.37 |
| Patient PICU admission weight (kg) | Median [IQR] | 26.5 [13.3, 49.0] | 30.7 [13.2, 59.0] | 0.21 |
| PRISM III score at PICU admission | Median [IQR] | 12 [8.0, 16] | 10 [5.0, 17] | 0.23 |
| Renal angina index at 12 hours of PICU admissiona | Median [IQR] | 8 [6, 24] | 15 [6, 40] | 0.26 |
| Time from PICU admission to CRRT initiation (d) | Median [IQR] | 4.5 [2.5, 12.5] | 2.3 [1.4, 5.8] | 0.002 |
| Fluid accumulation from PICU admission to CRRT initiation (%) | Median [IQR] | 12.1 [4.9, 20.3] | 4.1 [0.6, 12.2] | 0.0008 |
| PICU fluid accumulation >15% at CRRT initiation | Yes | 26 (36.6%) | 22 (20.6%) | 0.02 |
| PICU fluid accumulation >20% at CRRT initiation | Yes | 18 (25.4%) | 20 (18.7%) | 0.35 |
| Patient outcome measures | Pre-TF2 (n = 71) | Post-TF2 (n = 107) | ||
| Survival to CRRT D/C | Yes | 48 (67.6%) | 74 (69.2%) | 0.87 |
| Survival to PICU D/C | Yes | 33 (46.5%) | 70 (65.4%) | 0.02 |
| Pre-TF2 (n = 48) | Post-TF2 (n = 74) | |||
| CRRT duration among CRRT survivors (d) | Median [IQR] | 5.8 [2.9, 12.2] | 4.0 [1.9, 9.7] | 0.06 |
| Pre-TF2 (n = 33) | Post-TF2 (n = 70) | |||
| PICU LOS after CRRT D/C among PICU survivors (d) | Median [IQR] | 8.6 [4.5, 13] | 2.6 [0.7, 8.6] | 0.002 |
| Total PICU length of stay among PICU survivors (d) | Median [IQR] | 24 [12, 39] | 13 [6, 26] | 0.02 |
| Patients who received CRRT within 14 days of PICU admission (N = 151) | ||||
| Variable | Pre-TF2 (n = 56) | Post-TF2 (n = 95) | P-value | |
|---|---|---|---|---|
| Pre-CRRT patient demographics and fluid status | ||||
| PRISM III score at PICU admission | Median [IQR] | 12 [8.5, 16] | 10 [6, 17] | 0.28 |
| Time from PICU admission to CRRT initiation (d) | Median [IQR] | 2.7 [1.8, 6.1] | 1.7 [1.1, 3.9] | 0.006 |
| Fluid accumulation from PICU admission to CRRT initiation (%) | Median [IQR] | 11.7 [4.8, 20.4] | 3.7 [0.5, 12.1] | 0.0004 |
| PICU fluid accumulation >15% at CRRT Initiation | Yes | 22 (40.0%) | 18 (18.9%) | 0.007 |
| Patient outcome measures | Pre-TF2 (n = 56) | Post-TF2 (n = 95) | ||
| Survival to CRRT D/C | Yes | 36 (64.3%) | 68 (71.6%) | 0.37 |
| Survival to PICU D/C | Yes | 26 (46.4%) | 65 (68.4%) | 0.01 |
| Pre-TF2 (n = 36) | Post-TF2 (n = 68) | |||
| CRRT duration among CRRT survivors (d) | Median [IQR] | 5.8 [3.2, 12.2] | 4.2 [2.2, 9.7] | 0.07 |
| Pre-TF2 (n = 26) | Post-TF2 (n = 65) | |||
| PICU LOS after CRRT D/C among PICU survivors (d) | Median [IQR] | 7.9 [2.5, 11] | 2.5 [0.6, 6.5] | 0.01 |
| Total PICU length of stay among PICU survivors (d) | Median [IQR] | 17 [9, 31] | 11 [6, 20] | 0.08 |
CRRT, continuous renal replacement therapy; IQR, interquartile range; PICU, pediatric intensive care unit; PRISM, pediatric risk of mortality; TF2, TAKING FOCUS 2.
a
n = 61 for pre-TF2 and 86 for TF2 eras as patients <3 months of age or with ESRD do not receive an RAI calculation.