Table 3.
Mediation analyses displaying the total, direct, indirect effects and the percentage of total effect mediated between advertises and psychosis, via cannabis use patterns
| Panel A. Main analyses on total exposure to adversity | |||||||
|---|---|---|---|---|---|---|---|
| Childhood adversities and potential mediators | Total | Direct | Indirect | ||||
| Coef. (s.e.) | p value | Coef. (s.e.) | p value | Coef. (s.e.) | % Mediated | p value | |
| Household discord – total Lifetime cannabis use Cannabis potency Cannabis frequency |
0.451 (0.115) 0.411 (0.106) 0.404 (0.146) |
<0.001 <0.001 0.006 |
0.373 (0.116) 0.352 (0.106) 0.287 (0.146) |
0.001 0.001 0.050 |
0.078 (0.022) 0.059 (0.018) 0.117 (0.038) |
17.25 14.37 28.94 |
<0.001 0.001 0.002 |
| Sexual abuse – total Lifetime cannabis use Cannabis potency |
0.460 (0.201) 0.418 (0.180) |
0.022 0.020 |
0.377 (0.201) 0.338 (0.181) |
0.061 0.061 |
0.082 (0.034) 0.078 (0.029) |
17.83 19.12 |
0.016 0.005 |
| Panel B. Sensitivity analyses restricted to early exposure to adversity | |||||||
| Childhood adversities and potential mediators |
Total | Direct | Indirect | ||||
| Coef. (s.e.) | p value | Coef. (s.e.) | p value | Coef. (s.e.) | % Mediated | p value | |
| Household discord – early Lifetime cannabis use Cannabis potency Cannabis frequency |
0.581 (0.137) 0.518 (0.128) 0.530 (0.178) |
<0.001 <0.001 0.003 |
0.498 (0.138) 0.468 (0.128) 0.404 (0.178) |
<0.001 <0.001 0.023 |
0.083 (0.026) 0.050 (0.022) 0.126 (0.046) |
14.26 9.63 23.77 |
0.002 0.024 0.006 |
| Psychological abuse – early Lifetime cannabis use Cannabis potency |
0.369 (0.256) 0.331 (0.229) |
0.149 0.148 |
0.261 (0.256) 0.228 (0.230) |
0.308 0.321 |
0.108 (0.045) 0.104 (0.041) |
29.16 31.28 |
0.017 0.011 |
Following Baron and Kenny criteria, mediation analyses have been conducted when the mediator is both associated with the predictor (adversities) and with the outcome simultaneously, based on analyses shown in Tables 1 and 2. Panel A refers to total exposure to adversity, while panel B shows the results of the sensitivity analyses restricted to early exposure to adversity (0–12 years).
Total effect, direct effect + indirect effect; direct effect, effect of the independent variable to the outcome variable; indirect effect, effect of the independent variable to the mediator and of the mediator on the outcome variable.
SE, standard error. Bold text indicates associations where p < 0.05.