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. 2023 Nov 30;10:1287312. doi: 10.3389/fnut.2023.1287312

Figure 2.

Figure 2

Evaluation of the effect of plant-derived miRNA mimics (A) miR482f and (B) miR482c-5p on the viability/proliferation of THP-1 macrophage-like cells. THP-1 monocytes differentiated to macrophages for 48 h were transfected with 60 nM of miRVana mimics miR482f (5′-UCUUUCCUACUCCACCCAUUCC-3′), miR482c-5p (5′-GGAAUGGGCUGUUUGGGAUG-3′), and a scramble sequence as a negative control (NC). Cell viability/proliferation was evaluated in THP-1 macrophage-like cells after 48 h of transfections. Results are the mean percentage ± standard error of the mean (SEM) relative to the cells transfected with the scramble sequence (negative control) (n = 4 independent experiments; NC: n = 13; miR482f: n = 13; miR482c-5p: n = 13). NC, negative control. Significance refers to the effect of miR482f or miR482c-5p with respect to the negative control. p-value: ** p < 0.01.