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. 2023 Nov 30;17:1294567. doi: 10.3389/fnins.2023.1294567

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Copyright © 2023 Dvorak, Di Re, Vasquez, Marosi, Shah, Contreras, Bernabucci, Singh, Stallone, Green and Laezza.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cocaine differentially regulates FGF13 mRNA levels in environmentally enriched versus environmentally isolated conditions. Bar graph comparing FGF13 mRNA levels in the NAcSh of either environmentally enriched or isolated rats that self-administered saline or cocaine. A significant main effect of cocaine (shown) and an interaction effect (cocaine × housing effect) were found. Data are mean ± SEM (n = 7–8 rats/group). Significance was assessed with a likelihood ratio F-test (^**p < 0.01).