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. 2023 Nov 30;17:1294567. doi: 10.3389/fnins.2023.1294567

Figure 3.

Figure 3

FGF13 regulates the excitability of MSNs of the NAcSh. (A) Staining of FGF13 at the AIS. Representative image of DAPI (blue), AnkyrinG (green) and FGF13 (red) at the AIS in the NAcSh with overlay and zoom to AIS. Scale bars indicate 5 μm and 2 μm. (B) Representative traces of evoked APs of MSNs expressing AAV-shCTRL-GFP or AAV-shFGF13-GFP in response to the depicted current-clamp protocol. (C) Comparison of the IFF of MSNs expressing AAV-shCTRL-GFP (black) or AAV-shFGF13-GFP (blue) over a range of injected current stimuli. (D–H) Comparison of the Vthr for AP initiation (D), maximum rise of the AP upstroke (E), maximum decay of the AP downstroke (F), RMP (G), and Rin (H) between the indicated experimental groups. Data are mean ± SEM (n = 10 cells/group; slices from N = 3 rats/group). Statistical significance was assessed using a student’s t-test (ns, not significant; *p < 0.05). For detailed statistical information, refer to Supplementary Table S2.