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. 2023 Dec 13;29:169. doi: 10.1186/s10020-023-00758-8

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — The influence of CsA on NETs expression dependent on G6PD. A The activity and transcriptional level of G6PD in neutrophils from UC patients and HC (ns: not significance, **P < 0.01). B The activity and transcriptional level of G6PD in neutrophils treated with LPS with or without CsA (ns: not significance, **P < 0.01). C Immunofluorescence and ratio of fluorescence intensity of Sytox green to Hoechst 33342 in neutrophils stimulated by LPS at the presence of 6-AN; Green: Sytox green, Blue: Hoechst 33342 (****P < 0.0001 for neutrophils treated with LPS vs LPS + 6-AN). D Change of intracellular ROS level in neutrophils stimulated by LPS in the presence of 6-AN for 1 h (ns: not significance, ****P < 0.0001 for neutrophils treated with LPS vs LPS + 6-AN)