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. 2023 Oct 28;42(11):113330. doi: 10.1016/j.celrep.2023.113330

Figure 6.

Figure 6

1210-like and MGG4-like binding conformations are associated with functional differences

(A) Buried surface area (BSA) between the core epitope and heavy chain (HC; left) or kappa light chain (KC; right) of 1210- and MGG4-like mAbs.

(B) Total BSA between Fabs and core epitope for 1210- and MGG4-like mAbs.

(C) Theoretical change in free energy (ΔG) associated with binding of 1210- and MGG4-like mAbs to peptides based on crystallized Fab-peptide complexes.

(D) SPR binding profiles of 1210- and MGG4-like mAbs to indicated peptides, represented as log KD values. Error bars indicate standard deviation.

(E and F) In vivo liver burden reduction (E) and parasitemia protection (F) conferred by 1210- and MGG4-like mAbs.

(A–C and E) Horizontal lines represent arithmetic mean. n = 14 for 1210-like mAbs and n = 3 for MGG4-like mAbs (A–C); n = 7 for 1210-like mAbs and n = 3 for MGG4-like mAbs (E). Statistical significance was determined by two-tailed Mann-Whitney test: ∗p < 0.05, ∗∗p < 0.01.