Table 1. IC50 Values for Evaluated Molecules Employing Doxorubicin as a Standard Druga.
IC50 values (μM) |
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entry | compound | HepG2 | MCF7 | A549 | MCF-10A |
1 | 1 | 33.87 ± 3.34 | 39.76 ± 3.35 | 36.27 ± 3.37 | NT |
2 | 2 | 27.33 ± 3.87 | 29.39 ± 2.35 | 29.87 ± 3.05 | NT |
3 | 3 | 2.02 ± 0.15 | 1.61 ± 0.12 | 1.87 ± 0.32 | 77.29 ± 3.22 |
4 | 4a | 13.74 ± 3.81 | 14.27 ± 2.05 | 14.87 ± 3.12 | 60.12 ± 2.31 |
5 | 4b | 17.82 ± 2.04 | 18.76 ± 3.19 | 17.11 ± 3.17 | 58.12 ± 2.34 |
6 | 6 | 15.39 ± 3.12 | 15.21 ± 2.16 | 15.57 ± 2.94 | 57.02 ± 1.28 |
7 | 7 | 6.26 ± 0.32 | 5.60 ± 1.12 | 7.28 ± 1.34 | 78.54 ± 2.05 |
8 | 11 | 50.48 ± 3.16 | 60.10 ± 3.45 | 50.67 ± 3.23 | NT |
9 | 13 | 19.26 ± 2.07 | 18.09 ± 2.05 | 19.15 ± 3.88 | 51.57 ± 1.98 |
10 | 14 | 37.22 ± 1.45 | 39.33 ± 3.12 | 40.39 ± 3.15 | NT |
11 | 15 | 19.27 ± 2.06 | 19.27 ± 3.37 | 18.99 ± 3.45 | 52.33 ± 2.18 |
12 | 17 | 25.29 ± 1.34 | 29.02 ± 2.38 | 24.28 ± 3.88 | NT |
13 | 18 | 39.67 ± 1.22 | 45.62 ± 3.28 | 45.97 ± 3.65 | NT |
14 | 19 | 13.33 ± 1.96 | 15.21 ± 1.65 | 14.33 ± 1.96 | 60.45 ± 1.94 |
15 | doxorubicin | 2.71 ± 0.12 | 1.68 ± 0.11 | 2.22 ± 0.22 | 87.34 ± 1.47 |
The percentage inhibition (IC50) was determined from three successive tests utilizing an MTT procedure after 72 h of treatment. The statistics are reported as the mean standard deviation (S.D.). A standard drug is Doxorubicin. NT = Not Tested.