Cerchietti 2000.

Study characteristics
Methods	Randomised, comparative prospective, single‐centre trial Method of randomisation: unclear Blinding status: unclear Study duration: 48 hours
Participants	Prognosis ‐ terminal‐stage advanced cancer patients ≥ 1 of the following symptoms: thirst; chronic nausea or delirium; dehydration diagnosed on physical examination, with or without renal failure; and inability to maintain an adequate water intake (< 50 mL/day fluid) Sample size: 50 Exclusions: 4 uncontrolled symptoms (pain in 2, severe dyspnoea in 2), 1 bowel obstruction syndrome requiring surgery, 3 severe constipation Participants were recruited from Argentina.
Interventions	42 participants were randomised to 1 of 2 groups. Treatment (1000 mL 5% dextrose in water infusion with the addition of 140 mEq/L sodium chloride per day, at an infusion rate of 42 mL/hour subcutaneous (20 participants) Usual treatment: no subcutaneous fluids given (22 participants)
Outcomes	Primary outcomes (VAS): Thirst Chronic nausea Delirium MMSE Secondary outcomes: Anguish (measurement not defined) Mood (measurement not defined) Interruption of hydration (oedema, increase in respiratory secretions, congestive heart failure) Local adverse reactions
Identification
Notes	No conflicts of interest declared. No grants or support reported.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "randomly assigned", but method not adequately described. Comment: unclear if done
Allocation concealment (selection bias)	Unclear risk	Method used was not described. Comment: unclear if done
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No blinding described. Comment: unclear if done
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No blinding described. Comment: unclear if done
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Method not described. Comment: unclear if done
Selective reporting (reporting bias)	Unclear risk	Insufficient information presented. Comment: unclear if done