FIGURE 3.

MSM improves the glucose tolerance and insulin sensitivity of mice. (A–D) C57BL/6 male mice fed a high-fat diet (HFD) were treated with phosphate-buffered saline (PBS), 200 mg/kg/day p.o. MSM, or 400 mg/kg/day p.o. MSM for 4 weeks. Low-fat diet (LFD)-fed mice of the same age were used as a negative control. Glucose tolerance test (GTT) (A) and insulin tolerance test (ITT) (C) were conducted using LFD- or HFD-fed mice treated as indicated. The area under the curve was quantified from GTT (B) and ITT data (D). Data are represented as the mean ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001 (one-way ANOVA, followed by Tukey’s test).