Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Dec 13;223(1):e202308069. doi: 10.1083/jcb.202308069

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 Peglion and Etienne-Manneville

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Effects of altered cell polarity on cancer. Major cell polarity protein alterations leads to cancer initiation and progression in their respective organs. The figure highlights the different biological processes affected by the cell polarity alterations that directly fuel tumor formation and aggressive behavior. The processes include cellular growth, cell survival, tissue morphogenesis, cell fate, cell invasion and metastasis, cell metabolism, tumor microenvironment (stroma) identity, and resistance to both chemotherapy and immune clearance. Polarity protein Adenomatous Polyposis Coli (APC) alteration in immune T cells is not mentioned in the text but its consequence on pro-oncogenic stroma alteration has been added in this figure (Mastrogiovanni et al., 2022a, 2022b).