Table 1.
Univariate and multivariate Cox proportional hazard analyses of germinal centre properties in LNs of patients from Guy's TNBC cohort.
| Guy's TNBC cohort | Model P | Hazard ratio | 95% CI |
|---|---|---|---|
| Univariate distant metastasis free survival | |||
| LN‐positive TNBC (N = 57), involved LNs | |||
| Mean GC number per patient (<2 versus ≥2) | 0.04 | 0.454 | 0.23–0.95 |
| Mean GC area per patient (≤0.015 mm2 versus >0.015 mm2) | 0.03 | 0.441 | 0.21–0.92 |
| Mean GC circularity per patient (≤0.69 versus >0.69) | 0.03 | 0.335 | 0.13–0.85 |
| LN‐positive TNBC (N = 57), cancer‐free LNs | |||
| Mean GC number per patient (<2 versus ≥2) | 0.02 | 0.283 | 0.09–0.94 |
| Mean GC area per patient (≤0.015 mm2 versus >0.015 mm2) | 0.1 | 0.496 | 0.20–1.22 |
| Mean GC circularity per patient (≤0.69 versus >0.69) | 0.3 | 0.534 | 0.18–1.62 |
| LN‐negative TNBC (N = 39), cancer‐free LNs | |||
| Mean GC number per patient (<2 versus ≥2) | 0.002 | 0.14 | 0.03–0.63 |
| Mean GC area per patient (≤0.015 mm2 versus >0.015 mm2) | 0.02 | 0.22 | 0.05–0.98 |
| Mean GC circularity per patient (≤0.69 versus >0.69) | NA | NA | NA |
| Covariate P | Model P | Hazard ratio | 95% CI | |
|---|---|---|---|---|
| Multivariate distant metastasis‐free survival | ||||
| Adjusted for age at diagnosis, histological grade, and number of involved | ||||
| LN‐positive TNBC (N = 57), involved LNs | ||||
| Mean GC number per patient (<2 versus ≥2) | 0.05 | 0.03 | 0.431 | 0.18–1.01 |
| Mean GC area per patient (≤0.015 mm2 versus >0.015 mm2) | 0.04 | 0.02 | 0.422 | 0.19–0.94 |
| Mean GC circularity per patient (≤0.69 versus >0.69) | 0.03 | 0.04 | 0.262 | 0.08–0.86 |
| LN‐positive TNBC (N = 57), cancer‐free LNs | ||||
| Mean GC number per patient (<2 versus ≥2) | 0.08 | 0.03 | 0.329 | 0.09–1.15 |
| Mean GC area per patient (≤0.015 mm2 versus >0.015 mm2) | 0.13 | 0.05 | 0.485 | 0.19–1.25 |
| Mean GC circularity per patient (≤0.69 versus >0.69) | 0.33 | 0.2 | 0.520 | 0.14–1.92 |
| Adjusted for age at diagnosis, histological grade | ||||
| LN‐negative TNBC (N = 39), cancer‐free LNs | ||||
| Mean GC number per patient (<2 versus ≥2) | 0.04 | 0.06 | 0.20 | 0.04–0.95 |
| Mean GC area per patient (≤0.015 mm2 versus >0.015 mm2) | 0.19 | 0.2 | 0.352 | 0.07–1.66 |
| Mean GC circularity per patient (≤0.69 versus >0.69) | NA | NA | NA | NA |
Statistical significance was assessed using likelihood ratio tests.