Table 2.

Univariate and multivariate Cox proportional hazard analyses of sinus area in LNs of TNBC patients.

A. Guy's TNBC cohort	Covariate P	Model P	Hazard ratio	95% CI
Univariate distant metastasis‐free survival
LN‐positive TNBC (N = 57), involved LNs
Normalised sinus area (≤0.13 mm2 versus >0.13 mm2)		0.002	0.318	0.15–0.67
LN‐positive TNBC (N = 57), cancer‐free LNs
Normalised sinus area (≤0.13 mm2 versus >0.13 mm2)		0.5	0.793	0.38–1.64
LN‐negative TNBC (N = 39), cancer‐free LNs
Normalised sinus area (≤0.13 mm2 versus >0.13 mm2)		0.7	0.802	0.27–2.35
Multivariate distant metastasis‐free survival
LN‐positive TNBC (N = 57), involved LNs
Normalised sinus area (≤ 0.13 mm2 versus >0.13 mm2)	0.008	0.003	0.357	0.17–0.77
LN‐positive TNBC (N = 57), cancer‐free LNs
Normalised sinus area (≤0.13 mm2 versus >0.13 mm2)	0.063	0.05	0.837	0.40–1.74
LN‐negative TNBC (N = 39), cancer‐free LNs
Normalised sinus area (≤0.13 mm2 versus >0.13 mm2)	0.781	0.007	1.167	0.39–3.46
Multivariate distant metastasis‐free survival
Adjusted for mean GC count, age at diagnosis, histological grade, and involved LN number
LN‐positive TNBC (N = 57), involved LNs
Normalised sinus area (≤0.13 mm2 versus >0.13 mm2)	0.039	0.01	0.391	0.16–0.95
LN‐positive TNBC (N = 57), cancer‐free LNs
Normalised sinus area (≤0.13 mm2 versus >0.13 mm2)	0.528	0.05	0.752	0.31–1.83
Adjusted for mean GC count, age at diagnosis, and histological grade
LN‐negative TNBC (N = 39), cancer‐free LNs
Normalised sinus area (≤0.13 mm2 versus >0.13 mm2)	0.681	0.1	1.349	0.32–5.63

B. Tianjin TNBC cohort	Covariate P	Model P	Hazard ratio	95% CI
Univariate distant metastasis‐free survival
LN‐positive TNBC (N = 85), involved LNs
SCS width (≤ 20 μm versus >20 μm)		<0.001	0.130	0.06–0.30
LN‐positive TNBC (N = 85), cancer‐free LNs
SCS width (≤20 μm versus >20 μm)		<0.001	0.246	0.10–0.59
Multivariate distant metastasis‐free survival
Adjusted for total GC count
LN‐positive TNBC (N = 85), involved LNs
SCS width (≤20 μm versus >20 μm)	<0.001	<0.001	0.241	0.10–0.57
LN‐positive TNBC (N = 85), cancer‐free LNs
SCS width (≤20 μm versus >20 μm)	<0.001	<0.001	0.201	0.08–0.50
Multivariate distant metastasis‐free survival
Adjusted for total GC count, age, pTstage, pNstage, LVI, sTILs, and TILs
LN‐positive TNBC (N = 85), involved LNs
SCS width (≤20 μm versus >20 μm)	0.029	<0.001	0.334	0.13–0.89
LN‐positive TNBC (N = 85), cancer‐free LNs
SCS width (≤20 μm versus >20 μm)	0.010	<0.001	0.211	0.06–0.69

Statistical significance was assessed using likelihood ratio test.