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. 2023 Sep 30;11(10):973–984. doi: 10.1002/ueg2.12468

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© 2023 The Authors. United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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The schematic diagram (a) and mediation effects (b) of metabolic status, C‐reactive protein and INFLA score on the association of adiposity with risk of incident inflammatory bowel disease (IBD). The x‐axis represents the mediation effect estimates and the y‐axis represents the three different effects (mediating effect, direct effect, total effect). B1, B2, B3 showed the mediation effects of metabolic status, C‐reactive protein and INFLA score on the associations between body mass index and risk of IBD, and B4, B5, B6 showed the mediation effects of metabolic status, C‐reactive protein and INFLA score on the associations between waist circumference and risk of IBD. ACME, average causal mediation effects; ADE, average direct effects. The mediating effects of the three mediators (M1: metabolic status; M2: C reactive protein; M3: INFLA score) were separately examined in the individual structural equation model.