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In vitro efficacy. Cytotoxic activity of (a) SLAE-based ADCs, (b) LLAE-based ADCs, (c) mAb wt, drug-linkers, and isotype ADC on high antigen-expressing cancer cell lines. Cytotoxic activity of (d) SLAE-based ADCs, (e) LLAE-based ADCs, (f) mAb wt and drug-linkers on low antigen-expressing cancer cell lines. The means and the standard deviations are the results of 3 independent experiments performed in triplicates.
