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. 2023 Dec 15;133(24):e173160. doi: 10.1172/JCI173160

Figure 3. Endothelial deletion of ATGL accelerates atherosclerosis in the PCSK9 overexpression model.

Figure 3

(A) Schematic of experimental setup for AAV8-PCSK9 injection–induced atherosclerosis model. WD, Western diet. (B) Oil Red O staining of aortic arch in WT versus Atgl ECKO mice and quantification of Oil Red O–positive lesion area. **P < 0.01, t test. n = 8 mice/group. (C) LDLR protein levels in the liver of WT versus Atgl ECKO mice with or without AAV8-PCSK9 injection. (D–F) Plasma cholesterol, TG, and FFA measurements in WT versus Atgl ECKO mice at the indicated time points following AAV8-PCSK9 injection. n = 7–8.