Fig 6. Reduction in No.13-7 incubation period in ovinized mice after passage through deer.

Incubation period of No.13-7 inoculum in VRQ/VRQ genotype sheep is reduced by passage through deer. WTD scrapie in sheep has a shorter incubation time in ovinized transgenic mice (Tg338) when compared to the original No.13-7 inoculum and has a similar incubation time of 76 days post-inoculation (DPI) to that of another scrapie strain, x124. All inocula shown are from sheep with the VRQ/VRQ genotype.